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You need to go into your miniconda3 or anaconda3 folder and find this file (the path may be slightly different on your install, but you should be able to find it): This quick fix seems to provide a temporary solution until Anaconda gets the necessary updates: If you experience an error similar to 'Unable to load OpenGL library', install a patched pyopengl package from cryoem channel (as of ). These fixes have not yet made their way into Anaconda. The new Big Sur macOS release (fall 2020) broke some things in Python, which are only now (Dec 2020) getting fixed. GPU Support (Linux Only!): For features which support the GPU, please complete the standard source install instructions below, then follow the GPU instructions from the binary installation page. We normally try to support OS versions as much as 5-7 years old.

Note that even with a source build it may be difficult to get this working on systems with very old operating system installs.

We strongly suggest getting the base EMAN2 installed and working first, before trying to install any additional packages within the same conda environment. Be warned that sometimes installing another package may trigger a version change in one of EMAN2's dependencies, which may or may not be a problem, depending on which dependency it is. If you need to install other packages you wish to use in concert with EMAN2, you will need to install them within the EMAN2 environment.

We make use of the environment system in conda, the package manager, to isolate EMAN2 dependencies from other conda packages you may have installed. If you follow the instructions below, you should have a painless source build very quickly. While it may be possible to build the system without using Conda, we do not recommend doing this, and cannot provide support for a non-conda approach. Anaconda distribution has become ubiquitous for Python and R-based scientific computing and education over the last decade.

We use Conda for a working environment and most of the dependencies.

While the instructions look long, in reality it should only take 10-15 minutes to complete the entire process (with a decent network connection).

Standard instructions for establishing a build and runtime environment for EMAN/SPARX/SPHIRE on Linux and macOS

1 channel failed to install a dependency